Restoration of aged liver regeneration by youthful systemic factors via LTβ-driven hepatocyte reprogramming
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This study investigates how youthful systemic factors can restore liver regeneration in aged individuals, focusing on the role of lymphotoxin β (LTβ) signaling in hepatocyte reprogramming. The authors found that young B cells enhance liver regeneration in aged mice by promoting transient somatic reprogramming of periportal hepatocytes through LTβ/LTBR signaling. These findings suggest potential therapeutic strategies for improving liver regeneration in elderly patients, particularly in the context of liver transplantation.
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