September 15, 2026 · Journal of hepatology · DOI: 10.1016/j.jhep.2026.07.020

Liver transplantation for primary liver cancers in the era of transplant oncology

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The authors explore how liver transplantation (LT) can be optimized for patients with primary liver cancers, emphasizing the importance of a dynamic "window of eligibility" that considers tumor characteristics and patient response to therapy. They discuss the role of neoadjuvant treatments in expanding transplant candidacy and highlight the need for personalized approaches through emerging biomarkers to improve patient selection and post-transplant outcomes. The paper aims to address how LT can be effectively integrated into the evolving landscape of transplant oncology for better management of primary liver malignancies.

Vincenzo Mazzaferro, Matthias Pinter, Anjana Pillai, Carlo Sposito, Parissa Tabrizian

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