September 15, 2026 · Journal of hepatology · DOI: 10.1016/j.jhep.2026.03.024

Integrating systemic therapy in the earlier stages of liver cancer

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The authors explore the integration of systemic therapies in the earlier stages of liver cancer, specifically hepatocellular carcinoma (HCC) and biliary tract cancers (BTC), aiming to evaluate the potential benefits of combining local and systemic treatments. They discuss the challenges in trial design and endpoints, as well as the current data on adjuvant and neoadjuvant therapies, highlighting the promising yet uncertain future of these strategies as standard care.

Julien Edeline, Ming Kuang, Maria Reig, Valérie Vilgrain

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