Temozolomide and olaparib for the treatment of an ARID1A-mutated uterine carcinosarcoma: A case report
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The authors investigate the efficacy of combining temozolomide and olaparib in treating a patient with ARID1A-mutated uterine carcinosarcoma, a scenario that has not been previously reported in clinical practice. The case study demonstrates a complete radiographic response after four cycles of this regimen, suggesting potential benefits for biomarker-selected patients with this cancer type. The findings support further prospective studies to evaluate this treatment combination in genomically characterized gynecologic cancers.
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