September 5, 2026 · Gynecologic oncology reports · DOI: 10.1016/j.gore.2026.102195

The use of ex-vivo in-vitro maturation of ovarian tissues oocytes (OTO-IVM) for fertility preservation in gynaecologic cancers

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The authors investigate the potential of ex-vivo in-vitro maturation of ovarian tissue oocytes (OTO-IVM) as a fertility preservation method for women with gynaecologic cancers, particularly when traditional techniques are unsuitable. They present a case series of four women who underwent this procedure during oncologic surgeries, highlighting the experimental nature of OTO-IVM and its potential as a viable option for fertility preservation in challenging cases. The study underscores the need for further evidence to support the effectiveness of OTO-IVM in achieving live births.

Charissa Shu Ying Goh, Cheryl Jia Wei Lim, Qiu Ju Ng, Shi Hui Lee, Felicia Hui Xian Chin, Yu Hui Lim, Jessie Wai Leng Phoon, Yan Jia Sim, Joo Mong Lee, Melissa Durgahshree, Melinda Chan Ling Hou, Yee Shen Chong, Tat Xin Ee

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