Markedly elevated alpha-fetoprotein leading to the diagnosis of high-grade endometrial carcinoma during hepatocellular carcinoma surveillance
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The authors investigate the potential of alpha-fetoprotein (AFP) as a marker for aggressive histologic variants of endometrial carcinoma, particularly in patients undergoing surveillance for hepatocellular carcinoma (HCC). They present a case of a 70-year-old woman whose significantly elevated AFP levels led to the diagnosis of high-grade endometrial carcinoma, despite no evidence of HCC, underscoring the need to consider non-hepatic causes of AFP elevation in clinical practice.
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