Gynecologic oncology reports
Audio Summaries

Patient perspectives on post-operative direct oral anticoagulant for venous thromboembolism prevention in patients with gynecologic cancers undergoing laparotomy

Mar 20, 2026

This study aimed to evaluate patient satisfaction during the transition from low molecular weight heparin (LMWH) to direct oral anticoagulant (DOAC) apixaban for extended venous thromboembolism (VTE) prophylaxis in patients with gynecologic cancers undergoing laparotomy. The findings indicated that patients using DOAC reported higher satisfaction, experiencing less difficulty with treatment and lower concerns about medication costs compared to those on LMWH, while maintaining a low incidence of VTE and major bleeding.

Neoadjuvant chemotherapy in locally advanced clear cell carcinoma of the cervix leading to complete disease resolution; a case report

Mar 19, 2026

This case report explores the effectiveness of a novel neoadjuvant chemotherapy regimen (cisplatin/paclitaxel/pembrolizumab/bevacizumab) in treating a 46-year-old woman with locally advanced clear cell carcinoma of the cervix, a rare and challenging form of cervical cancer. The authors aim to determine whether this alternative treatment approach can lead to improved outcomes, as evidenced by the patient's complete disease resolution following treatment and surgery. They conclude that further research is warranted to establish optimal neoadjuvant therapies for this difficult-to-treat cancer type.

Unilateral cervical carcinoma in a septate uterus with double cervix: A case report and literature review

Mar 11, 2026

The authors aim to explore the challenges of diagnosing and managing cervical cancer in patients with Müllerian anomalies, specifically focusing on a case of unilateral invasive endocervical adenocarcinoma in a patient with a complete septate uterus and longitudinal vaginal septum. They highlight the difficulties in cytologic sampling due to altered anatomy, which can delay cancer detection, and emphasize the need for thorough anatomical assessments for accurate diagnosis and treatment. The case presented demonstrates successful management and the importance of individualized care in such complex scenarios.

Sentinel node technologies in low-resource settings: Current evidence and future perspectives

Mar 9, 2026

The authors aim to evaluate the feasibility and challenges of implementing sentinel lymph node (SLN) mapping in gynecologic oncology within low- and middle-income countries (LMICs). They highlight that while SLN mapping offers improved staging and reduced morbidity, barriers such as cost, tracer availability, and infrastructure limitations hinder its widespread adoption. The paper suggests that innovative solutions and international collaboration are essential for advancing SLN mapping and enhancing cancer care equity in these regions.

Radiation-specific sexual and reproductive health challenges in adolescent and young adults assigned female at birth: a mixed-methods study of unmet needs post pelvic radiotherapy

Mar 5, 2026

This study investigates the sexual and reproductive health (SRH) challenges faced by adolescent and young adult patients assigned female at birth (AFAB) following pelvic radiotherapy (RT) for cancer. The authors aimed to identify the impacts of RT on SRH, uncover unmet care needs, and highlight gaps in support services for this population. Findings revealed high rates of sexual dysfunction, intimacy disruption, and fertility-related distress, emphasizing the need for improved communication, education, and resources in survivorship care.

Symptom triad of primary cervical rhabdomyosarcomas as seen in a Nigerian tertiary hospital: A case series

Mar 5, 2026

This study aims to characterize the clinical presentation and management of primary cervical rhabdomyosarcomas (PCR) at a Nigerian tertiary hospital over a 12-year period. The authors identified nine cases, all of the embryonal variant, and found that a symptom triad of cervical mass, procidentia, and mucoid discharge should raise suspicion for PCR in reproductive-age women. The findings suggest a favorable prognosis, with most patients surviving without disease recurrence following surgical intervention and chemotherapy.

Highlighting the molecular refinement of NSMP endometrial cancer in a case of mesonephric-like adenocarcinoma

Mar 5, 2026

The authors aim to address the challenges of diagnosing and treating non-specific molecular profile (NSMP) endometrial cancer (EC) by presenting a case of a 71-year-old woman whose low-grade NSMP EC was reclassified as mesonephric-like adenocarcinoma following comprehensive histopathological reassessment. Through extended molecular profiling, they identified specific mutations and characteristics that aligned the tumor with the aggressive "Cluster 3" subgroup of NSMP tumors, leading to a tailored adjuvant treatment approach. This case highlights the heterogeneity within the NSMP subgroup and underscores the importance of molecular classification in guiding therapy.

Is pregnancy feasible in women with adult granulosa cell tumors, and how should recurrence during pregnancy be managed? A case report and literature review

Mar 2, 2026

The authors investigate the feasibility of pregnancy in women with adult granulosa cell tumors (aGCT) and the management of disease recurrence during gestation, highlighting the need for individualized treatment strategies. They present a case of a woman diagnosed with FIGO IC aGCT who experienced recurrences during pregnancy, successfully managed through surgical intervention while maintaining the health of both mother and child. This case underscores the complexities involved in treating aGCT during pregnancy and the necessity of a multidisciplinary approach for optimal outcomes.

Cost effectiveness analysis of immunotherapy regimens currently approved in advanced or recurrent endometrial cancer: An analysis of the NRG-GY 018, RUBY, and DUO-E trials

Mar 2, 2026

The authors aimed to evaluate the cost-effectiveness of FDA-approved immunotherapy regimens combined with chemotherapy for advanced or recurrent endometrial cancer, specifically in mismatch repair deficient (dMMR) and proficient (pMMR) cohorts. Their analysis revealed that pembrolizumab and durvalumab are more cost-effective than dostarlimab, primarily due to differences in maintenance therapy duration, while immunotherapy appears less cost-effective for the pMMR population.

Acute myocardial infarction caused by coronary tumor embolism from uterine leiomyosarcoma: a case report

Feb 27, 2026

The authors present a case of acute myocardial infarction (AMI) caused by coronary tumor embolism from uterine leiomyosarcoma, a phenomenon not previously reported in this type of cancer. They aim to highlight the importance of recognizing tumor embolism as a potential cause of AMI, emphasizing the need for mechanical intervention like aspiration thrombectomy, which was successfully employed in this case. The findings underscore the necessity for clinicians to consider tumor embolism in cancer patients presenting with unexplained cardiac symptoms.