July 28, 2026 · Gynecologic oncology reports · DOI: 10.1016/j.gore.2026.102167

Malignant transformation of mature ovarian teratoma into goblet cell adenocarcinoma: a case report

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This case report investigates the rare malignant transformation of a mature ovarian teratoma into goblet cell adenocarcinoma, a condition with undefined optimal management strategies. The authors present the clinical course of a 39-year-old woman and discuss the challenges in treatment, advocating for a histology-directed approach that aligns with gastrointestinal cancer therapies rather than traditional gynecologic regimens. They emphasize the need for further collaborative reporting to establish standardized treatment guidelines for this uncommon tumor type.

Chinmayi Aryasomayajula, Nichole Legaspi, Mai Elzieny, Hanlin L Wang, Ritu Salani, Peggy S Sullivan

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