Rescuing a refractory Leiomyosarcoma: ALK-DCTN1 fusion as a gateway to long-term control with Ceritinib
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The authors aim to highlight the potential of targeting rare molecular alterations, specifically the ALK-DCTN1 fusion, in advanced uterine leiomyosarcoma (uLMS) to improve treatment outcomes. They present a case of a 59-year-old woman with stage IV uLMS who achieved significant tumor regression and durable partial remission after treatment with the ALK inhibitor ceritinib, following multiple failed conventional therapies. This case emphasizes the critical role of comprehensive molecular profiling in identifying actionable targets for effective treatment in aggressive malignancies like uLMS.
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