July 26, 2026 · Gynecologic oncology reports · DOI: 10.1016/j.gore.2026.102168

<em>KAT6B/A::KANSL1</em> uterine sarcoma - A case with recurrences following uterine morcellation and the development of primary cell line model

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The authors investigate the characteristics and recurrence patterns of KAT6B/A::KANSL1 uterine sarcoma, particularly in relation to uterine morcellation during surgery. They present two case studies, highlighting the challenges of establishing primary cell line models from these tumors, which ultimately do not retain estrogen receptor expression despite the tumors being strongly ER-positive. The findings suggest that morcellation may elevate the risk of recurrence in this type of sarcoma.

Lauren Chen, Jiahui Liu, Isabelle Nechala, Pooja Praveen Kumar, Carol Ewanowich, Melissa Levecchia, Christa Aubrey, Yangxin Fu, Cheng-Han Lee

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