Preclinical in vitro and in vivo activity of trastuzumab deruxtecan against <em>ERBB2</em>-mutated cervical carcinomas with low HER2 expression
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The authors investigate the efficacy of trastuzumab deruxtecan (T-DXd) as a targeted therapy for cervical carcinomas with somatic HER2 mutations, specifically focusing on those with low HER2 expression. Their findings demonstrate that T-DXd significantly outperforms control treatments in both in vitro and in vivo models of HER2-S310F-mutated cervical cancer, suggesting it could be a promising therapeutic option for patients with recurrent cervical cancer harboring ERBB2 mutations.
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