September 18, 2026 · American journal of obstetrics and gynecology · DOI: 10.1016/j.ajog.2026.09.017

Standalone Salpingectomy for Primary Ovarian Cancer Prevention: A Cost-Effectiveness Analysis

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The authors aimed to evaluate the cost-effectiveness of standalone salpingectomy as a primary prevention strategy for ovarian cancer, independent of other surgical procedures. Their analysis revealed that while standalone salpingectomy is not cost-effective for individuals at average population risk, it becomes cost-effective for those with moderately elevated risk (relative risk of 1.5) at ages 45 and 50, and for all ages at a relative risk of 2.0. These findings suggest that standalone salpingectomy may be a viable option in a risk-stratified approach to ovarian cancer prevention.

Sonja Lazovic, Ling Chen, Kevin J Rouse, Katherine Fischkoff, Sarah Paraghamian, Larissa A Meyer, Jennifer S Ferris, Rafael Gonzalez, Katina Robison, Dawn L Hershman, Xiao Xu, Jason D Wright

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