September 8, 2026 · American journal of obstetrics and gynecology · DOI: 10.1016/j.ajog.2026.08.043

Management of Multiple Sclerosis During Pregnancy and the Reproductive Years in 2026: An Expert Clinical Review

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The authors aimed to update clinical recommendations for managing multiple sclerosis (MS) in women of reproductive age, particularly regarding the use of disease-modifying therapies (DMTs) during pregnancy and lactation. Through a systematic review of existing literature, they found that MS generally does not increase the risk of adverse pregnancy outcomes, and with careful management, DMTs can be used to maintain maternal health while minimizing fetal risks. The review emphasizes the importance of collaborative care and close monitoring, especially during the postpartum period and as women transition to gynecological care post-childbearing.

Alexandra Balshi, Ruth Dobson, Maria Houtchens, Kylie McConville, Thomas F McElrath, A Dessa Sadovnick, Martha Tesfalul, Kerstin Hellwig, Riley Bove

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