The Gray Journal
Audio Summaries

Early life adversity and polycystic ovary syndrome among North American pregnancy planners

Jun 24, 2026

This study investigates the relationship between early life adversities, specifically adverse childhood experiences (ACEs), and the prevalence of polycystic ovary syndrome (PCOS) among North American women planning pregnancy. The authors found that higher exposure to ACEs is significantly associated with an increased likelihood of self-reported PCOS, suggesting that childhood adversities may have long-lasting effects on gynecologic health. These findings highlight the importance of considering early life stressors in understanding the risk factors for PCOS.

The Role of Placental Anastomoses in Severe Brain Injury After Fetal Demise in Monochorionic Twins: A Multicenter Retrospective Study

Jun 22, 2026

The authors aimed to investigate the relationship between the number and diameter of placental anastomoses and the occurrence of severe brain injury in surviving monochorionic twins following a single fetal demise. Their findings indicate that larger diameters and greater numbers of both arterio-arterial and veno-venous anastomoses are associated with increased risk of severe brain injury, although no significant associations were found when focusing solely on cases of single fetal demise.

International Trends in Concurrent Hysterectomy at Risk-Reducing Surgery in BRCA1/2 pathogenic variant carriers: A mixed-methods study

Jun 20, 2026

This study investigates the international trends and decision-making factors surrounding the execution of concurrent hysterectomy during risk-reducing salpingo-oophorectomy (RRSO) in BRCA1/2 pathogenic variant carriers. The authors found significant regional variations in the practice, with much higher rates in North and South America compared to Europe and Australia, and identified various barriers and facilitators influencing these decisions, including cultural differences and the lack of clear guidelines.

Translation of Chronic Pelvic Pain Experience into Patient Treatment Preference Profiles with Q-Methodology

Jun 11, 2026

The authors aimed to develop a method for integrating patient perspectives into treatment choices for female chronic pelvic pain (FCPP) by utilizing Q-methodology. Through stakeholder input and patient advisory group collaboration, they identified five distinct patient preference profiles that can guide treatment counseling and improve patient engagement with FCPP therapies. This study provides a framework for measuring and applying patient viewpoints in clinical decision-making for FCPP.

Open Boari Flap Teaching Simulation using a Porcine Model

Jun 10, 2026

The authors aimed to address the lack of training opportunities for OB/GYN trainees in performing ureteral reimplantation and Boari flap creation, which are critical skills due to the serious nature of ureteral injuries during gynecologic surgery. They developed a high-fidelity simulation model using porcine bladders and assessed its effectiveness through pre- and post-simulation questionnaires, finding that participants reported increased confidence and familiarity with the procedure. This simulation model is proposed as a valuable addition to OB/GYN training programs to enhance technical skills in complex ureteral repairs.

Assessment of laparotomy conversion, unplanned readmission, and perioperative mortality for minimally invasive surgery in endometrial cancer

Jun 9, 2026

The authors aimed to compare laparotomy conversion rates, unplanned readmission, and perioperative mortality between robotic-assisted and conventional laparoscopic hysterectomy for endometrial cancer. Their findings indicate that robotic-assisted hysterectomy is associated with significantly lower rates of laparotomy conversion, unplanned readmission, and perioperative mortality compared to conventional laparoscopic surgery. The study highlights a decrease in laparotomy conversion rates over time, suggesting potential advantages of robotic-assisted techniques in this surgical context.

Maternal Mortality, Birthweight and Immunogenetics: An Evolutionary Framework for Obstetric Risk

Jun 6, 2026

The authors explore the evolutionary framework surrounding maternal mortality and birthweight, addressing how the interplay between pelvic constraints and fetal brain size contributes to obstetric risks. They investigate the role of immunogenetic factors, particularly KIR-HLA interactions, in influencing reproductive outcomes and the incidence of complications such as pre-eclampsia and obstructed labor. Ultimately, the study aims to enhance understanding of the evolutionary origins of childbirth-related risks and speculate on the implications of modern medical practices on these conditions.

Combinational Tocolysis: Evaluating Lower-Dose Combinations of Nifedipine, Indomethacin and Aminophylline for Tocolytic Synergism in Pregnant Human Myometrium

Jun 5, 2026

The authors aimed to determine whether lower-dose combinations of the tocolytics nifedipine, indomethacin, and aminophylline could produce synergistic effects in inhibiting contractions of pregnant human myometrial tissue. Their findings revealed that dual combinations of nifedipine with either indomethacin or aminophylline, as well as the triple combination of all three drugs, demonstrated significant synergism, suggesting that these combinations could enhance tocolytic efficacy while minimizing side effects. This study supports the potential for further clinical investigation into combinational tocolysis to improve outcomes in preterm birth management.

Outcome of cesarean scar ectopic pregnancy continued to viability: Data from the International CSEP Registry

Jun 5, 2026

This study aims to characterize the outcomes of cesarean scar ectopic pregnancies managed expectantly and to identify ultrasound findings associated with the need for peripartum hysterectomy. Analyzing data from 115 viable cases, the authors found that expectant management poses significant risks, including a 67% live birth rate but a high incidence of peripartum hysterectomy, particularly in cases with a residual myometrial thickness of less than 2.5 mm and enhanced subplacental vascularity. These results highlight the necessity of early ultrasound evaluations to identify high-risk pregnancies and improve management strategies.

The effect of myo-inositol supplementation on gestational diabetes mellitus prevention: a systematic review and meta-analysis

Jun 4, 2026

This systematic review and meta-analysis aimed to evaluate the effectiveness of myo-inositol supplementation in preventing gestational diabetes mellitus (GDM) among women without pre-existing diabetes during pregnancy or the preconception period. The results indicated that myo-inositol significantly reduced the risk of GDM by 44%, while showing no significant impact on secondary maternal and neonatal outcomes. The findings suggest that myo-inositol is a promising and safe preventive strategy for GDM, potentially enhancing maternal metabolic health.