Early pregnancy oxylipin markers of inflammation and oxidative stress are associated with small-for-gestational-age birth and specific phenotypes of fetal growth restriction

The authors aimed to investigate the relationship between early pregnancy oxylipin biomarkers of inflammation and oxidative stress and the occurrence of small-for-gestational-age (SGA) and large-for-gestational-age (LGA) births, as well as specific phenotypes of fetal growth restriction. They found that certain oxylipins, particularly a urinary metabolite of thromboxane-A2, were significantly associated with SGA births and distinct phenotypes of fetal growth restriction, suggesting that these biomarkers could be valuable for early prediction and intervention in cases of fetal growth issues.