The role of misclassification in progression of CIN2 during active surveillance: results from a historical cohort

The study investigates the impact of misclassification of cervical intraepithelial neoplasia grade 2 (CIN2) diagnoses on the progression to CIN3 or worse during active surveillance in younger women. By reviewing histological diagnoses of cervical biopsies from a historical cohort, the authors found significant interobserver variability, with nearly half of the CIN2 cases being reclassified, highlighting the need for more accurate diagnostic methods and individualized management strategies that consider virological and cytological factors.