Late-Onset Diagnosis of Gestational Diabetes After Normal Mid-Pregnancy Screening in Women with Large for Gestational Age or Polyhydramnios: A Systematic Review and Meta-Analysis

The authors aimed to determine the detection rate of late-onset gestational diabetes mellitus (GDM) in women with normal mid-pregnancy glucose screening who undergo repeat testing due to suspected large-for-gestational-age (LGA) fetuses or polyhydramnios. They found that late OGTT detects GDM in approximately 15% of these women, with significantly higher rates of neonatal hypoglycemia and cesarean deliveries associated with late-onset GDM. These findings highlight the importance of repeat glucose testing in the third trimester for at-risk populations.