Neonatal and Obstetric Outcomes Following Periconceptional Exposure to Glucagon-Like Peptide-1 Receptor Agonists: A Systematic Review and Meta-analysis

The authors aimed to evaluate the impact of periconceptional exposure to glucagon-like peptide-1 receptor agonists on neonatal and obstetric outcomes. Their systematic review and meta-analysis of 22 studies found no significant associations with major adverse outcomes, although a small association with renal malformations was noted, likely influenced by confounding factors. The findings suggest that while there is no consistent evidence of harm, caution is warranted regarding the use of these medications during pregnancy, and further research is needed.