Planning and feasibility of phase III surgical trials in gynecologic oncology

The authors aim to address the challenges and considerations involved in planning phase III surgical trials in gynecologic oncology, emphasizing the need for rigorous pre-trial processes to ensure ethical justification and feasibility. They explore key components such as establishing equipoise, defining research questions, conducting feasibility studies, engaging patients and stakeholders, and navigating ethical and regulatory obligations. This foundational work is critical for the successful execution of surgical randomized controlled trials that can ultimately enhance patient care in gynecologic malignancies.