September 21, 2026 · Gynecologic oncology · DOI: 10.1016/j.ygyno.2026.09.010

Feasibility of real-time near-infrared fluorescence tracer imaging in sentinel lymph node biopsy for vulvar cancer patients

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The authors aimed to evaluate the feasibility and efficacy of hybrid indocyanine green (ICG) and technetium-99 m-labeled radiocolloid (99mTc-Nanocoll) in sentinel lymph node biopsy (SLNB) for patients with early-stage vulvar cancer. Their findings indicate that this hybrid approach is highly effective in detecting sentinel nodes, including those missed by preoperative imaging, while maintaining low rates of groin recurrence and favorable survival outcomes. Overall, the study supports the safety and effectiveness of using ICG in conjunction with traditional methods for SLNB in this patient population.

Ligita Paskeviciute Frøding, Anders Christensen, Elisabeth Kristensen, Jann Mortensen, Karina Juhl, Tine Henrichsen Schnack

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