Serous borderline tumor progressing to low-grade serous carcinoma after 35 years: a case of extended latency with molecular evidence of clonal relationship

The authors investigate the prolonged latency period between the diagnosis of a serous borderline ovarian tumor (SBOT) and its progression to low-grade serous ovarian carcinoma (LGSOC), presenting a case where this transition occurred after 35 years. They provide molecular evidence of a clonal relationship between the two tumors through the identification of a BRAF V600E mutation, which also guided targeted therapy for the patient. This case underscores the importance of molecular testing in understanding tumor progression and informing treatment strategies.