September 2, 2026 · Journal of hepatology · DOI: 10.1016/j.jhep.2026.04.017

Artificial intelligence and personalised medicine in liver cancer

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The authors explore how artificial intelligence (AI) can enhance personalized medicine in the management of liver cancer, specifically hepatocellular carcinoma and cholangiocarcinoma. They highlight the potential of AI to integrate complex multimodal data—such as clinical, imaging, and pathological information—to improve diagnosis, prognostication, and treatment selection, while also addressing the challenges of clinical translation and model interpretability. Ultimately, they suggest that successful implementation of AI-driven systems could significantly advance personalized care in this complex disease.

Nickolai Joel Matuschewski, William Baker, Julius Chapiro, Julien Calderaro

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