Neonatal outcomes in gestational diabetes trials: What clinicians should consider when interpreting treatment effects

The authors investigate how the interpretation of neonatal outcomes in gestational diabetes trials can be influenced by the choice of treatment effects, composite endpoints, and definitions of fetal growth standards. They emphasize the importance of using clinically coherent outcomes and reporting both absolute birth weight thresholds and percentile-based measures to accurately assess treatment benefits and potential overtreatment. The review calls for transparency in the reporting of neonatal outcomes and the methodologies used to define them, highlighting the need for sensitivity analyses across different growth charts.