H3.1 Nucleosomes to Predict Renal Replacement Therapy and Mortality in Sepsis-A Secondary Analysis of the SISPCT Randomized Control Trial
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The authors aimed to determine whether plasma H3.1 nucleosome levels could serve as predictive biomarkers for the need for renal replacement therapy (RRT) and 28-day mortality in patients with sepsis and septic shock. Their analysis revealed that elevated admission H3.1 levels were significantly associated with increased mortality and a higher likelihood of requiring RRT, suggesting that H3.1 nucleosomes may be valuable indicators of patient outcomes in sepsis.
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