Impact of surveillance colonoscopy on colorectal cancer incidence and mortality in Lynch syndrome: a national observational cohort study of patients in the English NHS 2010-2022
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The authors aimed to evaluate the adherence of MMR carriers in Lynch syndrome to national surveillance guidelines and assess the impact of colonoscopic surveillance on colorectal cancer (CRC) incidence and mortality. Their findings suggest that while regular surveillance (≤3 years) is linked to reduced CRC-specific and all-cause mortality, it did not significantly change total CRC incidence, and more frequent surveillance (≤2 years) was associated with increased CRC incidence, particularly of early-stage cancers. The study highlights potential biases and the need for further investigation into the effects of surveillance on CRC outcomes.
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