Faecal proteases and immune signatures drive subtype-specific enteric neuronal activation in IBS
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The authors investigate how faecal mediators differentially activate enteric neurons in patients with different subtypes of irritable bowel syndrome (IBS) and whether specific proteolytic and proteomic profiles can explain these neuronal responses. Their findings reveal that faecal supernatants from IBS-D patients significantly enhance neuronal activation via proteases and PAR-1, while IBS-C mediators do not exhibit this effect, indicating distinct pathological mechanisms between the two subtypes. This study highlights a novel connection between faecal protease activity, enteric nervous system signaling, and immune profiles, suggesting new diagnostic and therapeutic strategies for managing IBS based on subtype.
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