Dexamethasone-Free Antiemetic Prophylaxis for Children and Adolescents Receiving Highly Emetogenic Chemotherapy: A Multicenter, Phase III, Noninferiority Trial (CIVIC POD)
Listen to this summary
The study aimed to determine whether olanzapine could serve as a noninferior alternative to the standard dexamethasone-based regimen for preventing chemotherapy-induced nausea and vomiting (CINV) in children and adolescents receiving highly emetogenic chemotherapy. The results indicated that olanzapine provided comparable control of vomiting without the use of dexamethasone, suggesting it may be a viable corticosteroid-sparing option for pediatric CINV prophylaxis. However, olanzapine was associated with a higher incidence of somnolence.
This is one of 33,000+ journals available on OSLR. Try it free for 14 days.
Free 14-day trial. 33,000+ journals. Cancel anytime.
More from Journal of clinical oncology : official journal of the American Society of Clinical Oncology
View all →Aug 7, 2026 · Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Contemporary Management of Relapsed or Refractory Chronic Lymphocytic Leukemia
Aug 6, 2026 · Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Systemic Therapy in Patients with Metastatic Castration-Resistant Prostate Cancer: ASCO Living Guideline, Version 2026.1.4
Aug 6, 2026 · Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Longitudinal Change in Cardiac Function After Doxorubicin and Dexrazoxane: A Report From Children's Oncology Group ALTE11C2
Aug 3, 2026 · Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Impact of Tumor Genomic Profile on Adjuvant Chemotherapy Efficacy in Resected Pancreatic Adenocarcinoma: Results From the PRODIGE-24/CCTG PA6 Study
Aug 3, 2026 · Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Darolutamide Alone and in Combination With Goserelin in Androgen Receptor-Positive Salivary Gland Carcinoma: Results From the Phase II DISCOVARY Trial
Jul 31, 2026 · Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Long-Term Analysis of Patients With Ewing Sarcoma Included in the Euro-EWING99 Study
More in Pediatrics
View all →Aug 7, 2026 · European heart journal
Temporal comparison of clinical practice and outcomes in heart failure: the JROADHF and JROADHF-NEXT studies
Aug 7, 2026 · Critical care medicine
Geographic Access to Care and Mortality in Cardiogenic Shock: A Nationwide Cohort Analysis
Aug 7, 2026 · Pediatric nephrology (Berlin, Germany)
Anti-rituximab antibodies: implications for clinical outcomes and safety in pediatric idiopathic nephrotic syndrome
Aug 7, 2026 · Critical care medicine
Rethinking Muscle Wasting in Critical Illness: A Systematic Review and Meta-Analysis of Myofiber Size and Protein Turnover
Aug 7, 2026 · Critical care medicine
Telemedicine Critical Care Billing For Hospitalized Medicare Fee-For-Service Beneficiaries, 2018-2024
Aug 7, 2026 · European heart journal
Bruton's tyrosine kinase inhibitors and cardiovascular risk: a meta-analysis
"Oslr has become part of my weekly routine on my day off. The clinical relevance of the summaries is outstanding — I'd rate it 9/10. Being able to consume research hands-free is a huge advantage for busy physicians."
Dr. Jennifer Thompson
Portland, OR
Stay current without falling behind
33,000+ journals. 3-minute audio summaries. Free for 14 days.
