Darolutamide Alone and in Combination With Goserelin in Androgen Receptor-Positive Salivary Gland Carcinoma: Results From the Phase II DISCOVARY Trial
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The authors aimed to evaluate the efficacy and safety of darolutamide, both as a monotherapy and in combination with goserelin, in patients with androgen receptor-positive unresectable locally advanced or recurrent/metastatic salivary gland carcinoma. The results indicated that while darolutamide alone showed limited antitumor activity, the combination with goserelin significantly improved objective response rates and progression-free survival, suggesting a potential chemotherapy-sparing treatment option for this aggressive malignancy.
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