July 31, 2026 · Journal of clinical oncology : official journal of the American Society of Clinical Oncology · DOI: 10.1200/JCO-25-02516

Long-Term Analysis of Patients With Ewing Sarcoma Included in the Euro-EWING99 Study

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The Euro-EWING99 study aimed to analyze the characteristics and outcomes of patients with Ewing sarcoma (EWS) to identify prognostic factors influencing survival. With a cohort of 3,395 patients, the study found that overall survival and progression-free survival rates were significantly associated with metastatic status, patient age, tumor volume, and histologic response after neoadjuvant therapy. This research represents the largest series of EWS patients to date and underscores the importance of complete histologic response as a major prognostic indicator.

Thibaud Valentin, Sarah Winter, Uta Dirksen, Douglas S Hawkins, Hans Gelderblom, Séverine Risbourg, Pablo Berlanga, Nathalie Gaspar, Katerine A Janeway, Heribert Juergens, Ina Elisa Kirchberg, Ruth Ladenstein, Valérie Laurence, Marie-Cécile Le Deley, Martin G McCabe, Hans Merks, Andreas Ranft, Sandra Strauss, Michiel A J Van De Sande, Jeremy Whelan, Perrine Marec-Berard, Bernadette Brennan

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