Theca cells: active orchestrators of ovarian aging
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The authors investigate the role of theca cells in ovarian aging, challenging the prevailing focus on oocytes and granulosa cells by highlighting the decline and dysfunction of theca cells as critical factors in this process. They detail how age-related changes in theca cells contribute to impaired steroidogenesis, inflammation, and follicular atresia, while also suggesting potential therapeutic strategies to restore their function. This review emphasizes the need to consider theca cells as active participants in ovarian aging, advocating for the development of targeted interventions and biomarkers.
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