July 17, 2026 · Reproductive biology and endocrinology : RB&E · DOI: 10.1186/s12958-026-01590-5

Injury and recovery patterns of the blood-testis barrier and spermatogenic function in a surgical unilateral cryptorchidism model in rats

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The authors aimed to investigate the injury and recovery patterns of the blood-testis barrier (BTB) and spermatogenic function in a surgical unilateral cryptorchidism model in rats. Their findings indicate that while short-term cryptorchidism leads to reversible testicular atrophy and spermatogenic dysfunction, prolonged retention (4 weeks or longer) results in irreversible BTB damage and persistent spermatogenic abnormalities.

Yan He, Run-Long Wang, Li-Peng Li, Hao-Xuan Yang, Yi-Fei Liu, Wen-Nuo Zhang, Hao-Yang Song, Ming-Xin Zhao, Jin-Chun Qi

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