Reproductive biology and endocrinology
Audio Summaries

Association of celiac disease with menstrual and hormonal disturbances: a systematic review and meta-analysis

Jun 23, 2026

This systematic review and meta-analysis aimed to evaluate the association between celiac disease (CD) and menstrual and hormonal disturbances in women. The findings indicate that women with CD experience a higher mean age at menarche, an increased risk of abnormal uterine bleeding, and amenorrhea, while biochemical hormonal markers remain unchanged compared to controls. The study highlights the negative impact of CD on menstrual health without significantly affecting hormonal levels.

Diagnosis-dependent metabolic reprogramming of follicular fluid

Jun 19, 2026

The authors aimed to characterize and compare the amino acid profiles in follicular fluid (FF) from patients undergoing in vitro fertilization (IVF) with various infertility-related disorders, including insulin resistance (IR), endometriosis (EM), and thyroid dysfunction (TD). Their findings indicate that while the overall amino acid composition of FF is largely conserved, specific metabolic alterations associated with each disorder can be detected, independent of body mass index (BMI). This study highlights the potential of using metabolic patterns in FF to enhance the understanding of reproductive dysfunction.

Does obesity affect serum anti-müllerian hormone or inhibin B levels in polycystic ovary syndrome? Results of a systematic review and meta-analysis

Jun 14, 2026

The authors aimed to determine whether obesity affects serum levels of anti-Müllerian hormone (AMH) and inhibin B (INHB) in women with polycystic ovary syndrome (PCOS). Their systematic review and meta-analysis of 38 studies revealed that obese women with PCOS had significantly lower levels of both AMH and INHB compared to non-obese counterparts, suggesting that obesity may influence ovarian reserve biomarkers in this population. The findings underscore the importance of considering weight status when interpreting these hormonal markers in PCOS.

How endometrial thickness affects pregnancy and perinatal outcomes: a retrospective study of 16,566 frozen-thawed single blastocyst transfer cycles

Jun 11, 2026

This study investigates the impact of endometrial thickness (EMT) on pregnancy and perinatal outcomes in 16,566 frozen-thawed single blastocyst transfer cycles. The authors found that an EMT of ≤ 7 mm is linked to lower live birth rates and higher risks of miscarriage and preterm birth, while an EMT > 10 mm is associated with improved live birth odds without increasing adverse outcomes. The findings suggest that EMT alone should not dictate the cancellation of embryo transfers, and that maternal age and BMI may influence these outcomes, indicating the need for personalized treatment approaches.

Optimal selection of ovarian stimulation protocol for infertile women with diminished ovarian reserve based on Bologna and POSEIDON criteria: a network meta-analysis

Jun 5, 2026

The authors aimed to determine the optimal ovarian stimulation protocol for infertile women with diminished ovarian reserve (DOR) by comparing five commonly used protocols through a network meta-analysis, stratified by Bologna and POSEIDON criteria. The findings suggest that the double ovarian stimulation (DOS) protocol is most effective for Bologna criteria patients, while the GnRH agonist protocol yields the best outcomes for POSEIDON group 3 patients. The study emphasizes the need for individualized stimulation strategies to improve clinical outcomes for DOR patients.

Pharmacodynamic interaction analysis of dydrogesterone, progesterone, and estradiol in combination-progestin HRT frozen embryo transfer: a prospective clinical cohort study

Jun 2, 2026

This study investigates the pharmacodynamic interactions between dydrogesterone (DYD), progesterone (P), and estradiol (E2) in the context of hormone replacement therapy for frozen embryo transfer (HRT-FET) in anovulatory women. The authors aim to determine how these hormones' independent and combined levels affect clinical outcomes, specifically live birth rates. Their findings suggest that higher concentrations of both DYD and P correlate with increased live birth rates, indicating potential additive effects that warrant further exploration in larger studies.

Enhanced genetic diagnosis in early pregnancy loss: an integrated approach using CNV-Seq and STR genotyping

May 29, 2026

The authors aimed to determine whether integrating copy number variation sequencing (CNV-seq) with short tandem repeat (STR) genotyping could enhance the diagnostic performance for chromosomal abnormalities in early pregnancy loss (EPL). Their study found that this combined approach improved detection rates, identifying additional cases of triploidy and uniparental disomy that were missed by CNV-seq alone, and provided insights into the parental origins of these abnormalities. Overall, the findings suggest that this integrated method offers a more comprehensive understanding of the genetic causes of EPL.

Endometriosis disrupts oocyte metabolism and cortical granule function, impairing fertilization

May 26, 2026

The authors investigate how endometriosis affects oocyte metabolism and cortical granule function, contributing to reduced fertilization rates. Using a mouse model, they found that endometriosis leads to increased reactive oxygen species, altered cortical granule exocytosis, and changes in actin architecture, ultimately impairing sperm-oocyte fusion while maintaining early embryonic activation capabilities. These findings enhance the understanding of the cytoplasmic defects associated with endometriosis and their impact on oocyte competence.

Decidualization potential of endometrial mesenchymal stem cells and their role in reproductive health

May 23, 2026

This review explores the decidualization potential of endometrial mesenchymal stem cells (eMSCs) and menstrual stem cells (MenSCs) and their critical roles in reproductive health, particularly in embryo implantation and pregnancy maintenance. The authors aim to elucidate how dysfunction in these stem cells is linked to pregnancy complications such as preeclampsia and endometriosis, while also highlighting their potential as diagnostic biomarkers and therapeutic targets in reproductive medicine.

Quantitative determination of vaginal diamines as a biomarker for vaginal dysbiosis and IVF-ET outcome

May 23, 2026

The authors aimed to investigate how controlled ovarian hyperstimulation (COH) affects vaginal microbiota and embryo implantation outcomes in women undergoing in vitro fertilization and embryo transfer (IVF-ET). Their findings revealed that COH significantly increased vaginal diamine levels and altered microbiota composition, with diamine concentrations above 9.5 µM correlating with higher rates of vaginal dysbiosis and embryo implantation failure. The study suggests that vaginal diamines may serve as a predictive biomarker for reproductive outcomes in IVF-ET.