July 10, 2026 · Reproductive biology and endocrinology : RB&E · DOI: 10.1186/s12958-026-01584-3

Immune escape in endometriosis: mechanisms, reprogramming strategies, and precision interventions

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The authors investigate the mechanisms of immune escape in endometriosis, aiming to understand how immune dysfunction contributes to the disease's persistence and recurrence. They synthesize recent findings on lesion-derived signals that impair immune responses and evaluate emerging immune-reprogramming strategies that could lead to non-hormonal therapies. The study highlights the need for further translational validation to effectively adapt oncology-derived approaches for treating this estrogen-dependent disorder.

Huiting Chen, Meng Zhang, Weidong Fei, Qiqin Zhang, Yujie Peng, Libo Zhu, Shaojie Ding, Xian Zhang, Zhengyun Chen, Mengdan Zhao

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