Immune escape in endometriosis: mechanisms, reprogramming strategies, and precision interventions

The authors investigate the mechanisms of immune escape in endometriosis, aiming to understand how immune dysfunction contributes to the disease's persistence and recurrence. They synthesize recent findings on lesion-derived signals that impair immune responses and evaluate emerging immune-reprogramming strategies that could lead to non-hormonal therapies. The study highlights the need for further translational validation to effectively adapt oncology-derived approaches for treating this estrogen-dependent disorder.