The endometriosis-adenomyosis spectrum: shared pathophysiology and microenvironment-driven disease divergence
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This review by Hiroshi Kobayashi explores the shared and divergent pathogenic mechanisms of endometriosis and adenomyosis, particularly how distinct microenvironments influence their development into different pathological phenotypes. The authors investigate the role of mitochondrial function, oxidative stress, and tissue-specific factors in driving these differences, proposing a model that links common stimuli to either proliferative or fibrotic disease progression. The findings aim to inform future precision therapeutic strategies for these gynecologic disorders.
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