Transcriptome analysis of follicular granulosa cells in young women with diminished ovarian reserve
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This study investigates the differential expression of microRNAs, long non-coding RNAs, and messenger RNAs in granulosa cells from young women with diminished ovarian reserve (DOR) to uncover potential molecular mechanisms underlying this condition. The authors found significant transcriptional alterations related to fatty acid metabolism, AKT-mTOR signaling, and apoptosis pathways, suggesting that these changes may contribute to DOR pathogenesis. The research also proposes competing endogenous RNA networks that could serve as targets for future studies on DOR.
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