July 20, 2026 · Mayo Clinic proceedings · DOI: 10.1016/j.mayocp.2026.07.008

Symptoms, Causes, and Treatment of Sarcoidosis

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This review article aims to provide an updated framework for clinicians to optimize the diagnosis and management of sarcoidosis, a complex multisystem granulomatous disorder of unknown cause. The authors discuss the challenges in diagnosing sarcoidosis due to its overlapping symptoms with other conditions, while summarizing recent advances in understanding its epidemiology, immunopathogenesis, and treatment options. Additionally, the paper addresses common clinical challenges and knowledge gaps in the field.

Kathryn T Del Valle, Neema Jayachamarajapura, Eva M Carmona

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