July 16, 2026 · Journal of cataract and refractive surgery · DOI: 10.1097/j.jcrs.0000000000002014

Enhancing Patient Comfort in Epi-Off Crosslinking: The Potential of High-O2 Chambers

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The authors aimed to evaluate the effects of a high-oxygen environment on the efficacy of epi-off corneal cross-linking (CXL) and patient comfort during the procedure. Their findings indicated that patients treated in a high-oxygen chamber experienced deeper stromal demarcation, better keratometric improvements, and significantly lower pain levels compared to those in ambient air. This suggests that high-oxygen conditions may enhance both clinical outcomes and patient experience in CXL procedures.

Abbas Mohammadi, Shima Dehghani, Heidar Abbas, Daniel Savage, Elham Ashrafi, Farhad Hafezi, Golshan Latifi, Amir Houshang Beheshtnejad, Fateme Alipour

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