July 29, 2026 · Journal of cataract and refractive surgery · DOI: 10.1097/j.jcrs.0000000000002030

Randomized, Controlled Cross-over Comparison of Oral Cannabidiol to Oral Opioid for Postoperative Photorefractive Keratectomy Pain Control

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The authors aimed to compare the safety and efficacy of low-THC oral cannabidiol (CBD) versus oral codeine-acetaminophen for managing postoperative pain after photorefractive keratectomy (PRK). The study found that CBD provided non-inferior pain control and similar recovery outcomes compared to codeine-acetaminophen, with only mild sensorium changes noted in patients taking CBD. This suggests that CBD may serve as a viable opioid-sparing alternative for pain management in refractive surgery.

Yujia Zhou, Kayla Swiatek, Andrew Nguyen, Sonal Tuli, Walter A Steigleman

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