Gut Microbiota Drives Aging-related Erythropoiesis Impairment via Phenylacetic Acid-induced Histone Phenylacetylation
Listen to this summary
This study investigates the role of gut microbiota in aging-related anemia, specifically how phenylacetic acid (PAA) produced by the gut symbiont Odoribacter splanchnicus contributes to impaired erythropoiesis through histone phenylacetylation. The authors demonstrate that elevated PAA levels disrupt erythroid differentiation in hematopoietic stem and progenitor cells by modifying chromatin accessibility at the GATA2 promoter. These findings highlight potential therapeutic strategies, including dietary phenylalanine restriction and HBO1 inhibition, to mitigate anemia in older adults.
This is one of 33,000+ journals available on OSLR. Try it free for 14 days.
Free 14-day trial. 33,000+ journals. Cancel anytime.
More from Blood
View all →Jul 9, 2026 · Blood
Neutrophils as chameleons of tissue inflammation and host-pathogen interactions
Jul 8, 2026 · Blood
USP22 is a novel vulnerability regulating MEIS1 protein abundance and gene transcription in KMT2Ar acute leukemia
Jul 8, 2026 · Blood
The CYB5R3 T117S Missense Variant is Associated with Attenuated Riociguat Efficacy in Sickle Cell Disease
Jul 8, 2026 · Blood
Rapid Peak Cilta-cel Expansion is Associated with Delayed Neurotoxicity in Multiple Myeloma
Jul 7, 2026 · Blood
Single Cell Analysis of the Tumor Microenvironment Landscape Across the Disease Spectrum of Multiple Myeloma
Jul 7, 2026 · Blood
Tagraxofusp, Azacitidine, and Venetoclax in Blastic Plasmacytoid Dendritic Cell Neoplasm
More in Internal Medicine
View all →Jul 10, 2026 · Reproductive biology and endocrinology : RB&E
Effect of uterine peristalsis at the time of embryo transfer on the outcomes of IVF cycles: a prospective cohort study
Jul 10, 2026 · JACC. Clinical electrophysiology
Beta-Blockers and Exercise Performance in Children with Long QT Syndrome
Jul 10, 2026 · Gut
Piezo2<sup>+</sup> mechanosensory neurons and glial cells initiate resident macrophage activation in postoperative ileus
Jul 10, 2026 · The American journal of sports medicine
Quantitative Investigation of Tibiofemoral Cartilage Early Degeneration After ACL Reconstruction: An Integrated Biomechanical and Longitudinal MRI Analysis
Jul 10, 2026 · JACC. Clinical electrophysiology
Comparison of Pacing Lead Design on Left Bundle Branch Pacing Outcomes: LEAD-LBBP Randomized Clinical Trial
Jul 10, 2026 · JACC. Clinical electrophysiology
MAGNETOcardiography Parameters to Predict Sudden Cardiac Death (MAGNETO-SCD) or Ventricular Events From Implantable Cardioverter Defibrillators
"Oslr has become part of my weekly routine on my day off. The clinical relevance of the summaries is outstanding — I'd rate it 9/10. Being able to consume research hands-free is a huge advantage for busy physicians."
Dr. Jennifer Thompson
Portland, OR
Stay current without falling behind
33,000+ journals. 3-minute audio summaries. Free for 14 days.
