July 9, 2026 · Blood · DOI: 10.1182/blood.2025029580

Neutrophils as chameleons of tissue inflammation and host-pathogen interactions

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This review explores the multifaceted roles of neutrophils beyond their traditional function in combating infections, particularly their involvement in cancer and chronic inflammation. The authors aim to elucidate the mechanisms by which neutrophils modulate immune responses through the release of various inflammatory mediators and the implications of granule dynamics in tissue inflammation and damage. They highlight the need for further research into neutrophil biology to better understand their contributions to disease and potential therapeutic strategies for modulation.

Yanfang Peipei Zhu, Sergio D Catz, Ben A Croker

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