Single Cell Analysis of the Tumor Microenvironment Landscape Across the Disease Spectrum of Multiple Myeloma
Listen to this summary
The authors aimed to investigate the evolution of the tumor microenvironment (TME) in multiple myeloma across different disease stages to better understand immune dysregulation and therapeutic resistance. By analyzing single-cell RNA and receptor sequencing data from 235 patients, they identified five distinct TME subtypes, or "ecotypes," that correlate with immune cell composition and clinical outcomes. Their findings highlight the importance of TME organization in disease progression and response to treatment, potentially guiding the development of targeted immunotherapies.
This is one of 33,000+ journals available on OSLR. Try it free for 14 days.
Free 14-day trial. 33,000+ journals. Cancel anytime.
More from Blood
View all →Jul 10, 2026 · Blood
Gut Microbiota Drives Aging-related Erythropoiesis Impairment via Phenylacetic Acid-induced Histone Phenylacetylation
Jul 9, 2026 · Blood
Neutrophils as chameleons of tissue inflammation and host-pathogen interactions
Jul 8, 2026 · Blood
The CYB5R3 T117S Missense Variant is Associated with Attenuated Riociguat Efficacy in Sickle Cell Disease
Jul 8, 2026 · Blood
Rapid Peak Cilta-cel Expansion is Associated with Delayed Neurotoxicity in Multiple Myeloma
Jul 8, 2026 · Blood
USP22 is a novel vulnerability regulating MEIS1 protein abundance and gene transcription in KMT2Ar acute leukemia
Jul 7, 2026 · Blood
Concurrent administration of BCMA and GPRC5D chimeric antigen receptor (CAR) T cells in advanced multiple myeloma
More in Internal Medicine
View all →Jul 10, 2026 · Reproductive biology and endocrinology : RB&E
Effect of uterine peristalsis at the time of embryo transfer on the outcomes of IVF cycles: a prospective cohort study
Jul 10, 2026 · JACC. Clinical electrophysiology
Beta-Blockers and Exercise Performance in Children with Long QT Syndrome
Jul 10, 2026 · Gut
Piezo2<sup>+</sup> mechanosensory neurons and glial cells initiate resident macrophage activation in postoperative ileus
Jul 10, 2026 · The American journal of sports medicine
Quantitative Investigation of Tibiofemoral Cartilage Early Degeneration After ACL Reconstruction: An Integrated Biomechanical and Longitudinal MRI Analysis
Jul 10, 2026 · JACC. Clinical electrophysiology
Comparison of Pacing Lead Design on Left Bundle Branch Pacing Outcomes: LEAD-LBBP Randomized Clinical Trial
Jul 10, 2026 · JACC. Clinical electrophysiology
MAGNETOcardiography Parameters to Predict Sudden Cardiac Death (MAGNETO-SCD) or Ventricular Events From Implantable Cardioverter Defibrillators
"Oslr has become part of my weekly routine on my day off. The clinical relevance of the summaries is outstanding — I'd rate it 9/10. Being able to consume research hands-free is a huge advantage for busy physicians."
Dr. Jennifer Thompson
Portland, OR
Stay current without falling behind
33,000+ journals. 3-minute audio summaries. Free for 14 days.
