July 10, 2026 · JACC. Clinical electrophysiology · DOI: 10.1016/j.jacep.2026.06.008

Comparison of Pacing Lead Design on Left Bundle Branch Pacing Outcomes: LEAD-LBBP Randomized Clinical Trial

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The LEAD-LBBP randomized clinical trial aimed to compare the outcomes of lumenless leads (LLLs) versus stylet-driven leads (SDLs) in patients undergoing left bundle branch pacing (LBBP). The study found that SDLs were associated with a higher incidence of left bundle branch capture loss, lower acute procedural success, and increased lead damage during implantation compared to LLLs. These results suggest that lead selection is critical for optimizing outcomes in LBBP procedures.

Eugene S J Tan, Rodney Soh, Jie-Ying Lee, Alfred Yip, Ming Ann Sim, Siew Pang Chan, Jerome Reymatias, Elaine Boey, Vern Hsen Tan, Colin Yeo, Wei Yao Lim, Kevin Leong, Wee Tiong Yeo, Swee-Chong Seow, Pipin Kojodjojo

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