June 26, 2026 · JACC. Clinical electrophysiology · DOI: 10.1016/j.jacep.2026.05.018

Repolarization and Activation Mapping in Ventricular Tachycardia Ablation: The REDEEM Study

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The REDEEM study aimed to evaluate a novel sinus rhythm mapping technique that combines repolarization and activation mapping to identify critical isthmus sites during ventricular tachycardia (VT) ablation. The findings demonstrated that the proposed method effectively identified anatomical associations with VT isthmus sites, with a notable overlap of repolarization cliffs and deceleration zones with VT exit and entrance sites. This study suggests the potential of the REDEEM method for improving VT ablation strategies, warranting further prospective validation.

Luigi Pannone, Antonio Bisignani, Pietro Rossi, Filippo Maria Cauti, Pasquale Vergara, Marco Polselli, Antonio Sorgente, Domenico Giovanni Della Rocca, Alvise Del Monte, Michele Magnocavallo, Ingrid Overeinder, Gezim Bala, Alexandre Almorad, Erwin Ströker, Juan Sieira, Mark La Meir, Pedro Brugada, Gian Battista Chierchia, Carlo de Asmundis, Stefano Bianchi, Andrea Sarkozy

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