June 26, 2026 · JACC. Clinical electrophysiology · DOI: 10.1016/j.jacep.2026.04.032

Early Safety Profile Using Pulsed Field Ablation: Prospective Multicenter DISRUPT-AF Study

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The DISRUPT-AF study aimed to evaluate the safety profile of pentaspline pulsed field ablation (PFA) for atrial fibrillation in a real-world setting across multiple centers in the U.S. The results indicated a low rate of procedure/device-related adverse events, with no significant injuries to critical structures such as the esophagus or phrenic nerve, suggesting a potentially safer alternative to traditional thermal ablation methods.

Elisabeth A Wong, Paul C Zei, Daniela Hincapie, Chang Dai, Bruce A Koplan, Stephen Ruble, Susan M Bezenek, Linda Justice, Andrea Natale, John Costello, Paari Dominic, Dwayne N Campbell, David Kessler, Weeranun D Bode, Paul R Coffeen, Michael Manogue, Joseph A Donnelly, Mark D Metzl, Jeremiah Wasserlauf, Yoel Vivas, Robert Eckart, Amit J Thosani, Frank Cuoco, Darren S Sidney, Guru P Mohanty, William A Belden, Mati S Friehling, Anish K Amin, Steven Bailin, Joshua Silverstein, Tharian S Cherian, Anil Rajendra, Jason D Meyers, Daniel Pelchovitz, John D Day, Jose Osorio, Amin Al-Ahmad, DISRUPT AF Investigators

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Early Safety Profile Using Pulsed Field Ablation: Prospective Multicenter DISRUPT-AF Study

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