June 26, 2026 · JACC. Clinical electrophysiology · DOI: 10.1016/j.jacep.2026.04.027

PVI Durability After PFA or RFA in Persistent-AF: Insights From a Mandated Prospective Remapping Study

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This study aimed to compare the durability of pulmonary vein isolation (PVI) and the rates of arrhythmia recurrence between pulsed field ablation (PFA) and radiofrequency ablation (RFA) in patients with persistent atrial fibrillation (AF). The results indicated that PFA and RFA had similar PVI durability (79% vs. 76%) and freedom from recurrence at one year, despite a significant number of patients experiencing AF recurrence even with durable PVI, suggesting the influence of non-pulmonary vein mechanisms in AF recurrence.

Oskar M Galuszka, Thomas Kueffer, Samuel H Baldinger, Helge Servatius, Claudia Herrera Siklódy, Nikola Kozhuharov, Gregor Thalmann, Antonio Madaffari, Andreas Haeberlin, Fabian Noti, Hildegard Tanner, Tobias Reichlin, Laurent Roten

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