The CYB5R3 T117S Missense Variant is Associated with Attenuated Riociguat Efficacy in Sickle Cell Disease
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The authors investigate the impact of the CYB5R3 T117S missense variant on the efficacy of riociguat, a soluble guanylyl cyclase stimulator, in patients with sickle cell disease. They find that this variant is associated with reduced effectiveness of riociguat, suggesting that CYB5R3 plays a crucial role in modulating nitric oxide signaling and vascular function in this condition.
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