USP22 is a novel vulnerability regulating MEIS1 protein abundance and gene transcription in KMT2Ar acute leukemia
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The authors investigate the role of USP22 in regulating MEIS1 protein stability and gene transcription in KMT2Ar acute leukemia, a subtype associated with poor prognosis and chemotherapy resistance. Through a genome-wide CRISPR/Cas9 screen, they identify USP22 as a crucial deubiquitinase that protects MEIS1 from degradation, thereby promoting leukemogenic transcription. The study suggests that targeting USP22 may offer a novel therapeutic strategy for treating KMT2Ar acute leukemias.
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