Concurrent administration of BCMA and GPRC5D chimeric antigen receptor (CAR) T cells in advanced multiple myeloma
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The authors aimed to evaluate the safety and efficacy of concurrent administration of BCMA and GPRC5D CAR T cells in patients with advanced multiple myeloma. In a phase I trial involving 15 heavily pre-treated patients, they found that the co-infusion resulted in a high overall response rate of 78% and a median progression-free survival of 18.2 months, while noting potential resistance mechanisms such as antigen loss and limited expansion of CAR populations. The study highlights the complexities of dual-targeted therapies in managing multiple myeloma.
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