June 22, 2026 · JAMA internal medicine · DOI: 10.1001/jamainternmed.2026.0996

Apolipoprotein L1 Gene Genotype and Kidney Outcomes After Living Kidney Donation

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The authors aimed to investigate the association between apolipoprotein L1 gene (APOL1) polymorphisms and kidney function outcomes following living kidney donation. Their findings indicate that Black kidney donors with high-risk APOL1 genotypes are at a significantly increased risk of developing reduced kidney function post-donation, suggesting that APOL1 genotyping should be considered for Black living donor candidates to improve risk assessment.

Chi-Yuan Hsu, Ying Gao, Barry I Freedman, Mitchell R Lunn, Anthony N Muiru, Mark A Schnitzler, Jasmin Divers, Roslyn B Mannon, Nicholette D Palmer, Amy B Karger, Krista L Lentine, Meyeon Park, Long-Term Kidney Transplantation Outcomes Network (APOLLO) Consortium

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