June 15, 2026 · JAMA internal medicine · DOI: 10.1001/jamainternmed.2026.1929

2024-2025 COVID-19 Vaccine and Major Adverse Cardiovascular Events Among US Veterans

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The study aimed to determine whether the 2024-2025 COVID-19 vaccine reduces the risk of COVID-19-associated major adverse cardiovascular events (MACEs) among US veterans. The findings indicated that the vaccine was associated with a 37.7% reduction in COVID-19-associated MACEs, particularly in individuals over 75 years old and those with comorbidities, while also showing a more substantial reduction in all-cause MACEs. This suggests that the vaccine may provide broader protective benefits beyond COVID-19-related complications.

Miao Cai, Yan Xie, Ziyad Al-Aly

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